BDBM50076813 CHEMBL10687::Lithium; (S)-2-({5-[5-(2-methoxy-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate

SMILES: COc1ccccc1-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1

InChI Key: InChIKey=ODRIJWKMQUKGQK-NDEPHWFRSA-M

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50076813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50076813 (CHEMBL10687 | Lithium; (S)-2-({5-[5-(2-methoxy-phe...) Show SMILES COc1ccccc1-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-8-4-5-9-24(21)27-18-22(12-14-25(27)31(34)33-28(32(35)36)16-17-40-3)19-38-20-23-13-15-30(39-23)26-10-6-7-11-29(26)37-2/h4-15,18,28H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50076813 (CHEMBL10687 | Lithium; (S)-2-({5-[5-(2-methoxy-phe...) Show SMILES COc1ccccc1-c1ccc(COCc2ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c2)-c2ccccc2C)o1 Show InChI InChI=1S/C32H33NO6S/c1-21-8-4-5-9-24(21)27-18-22(12-14-25(27)31(34)33-28(32(35)36)16-17-40-3)19-38-20-23-13-15-30(39-23)26-10-6-7-11-29(26)37-2/h4-15,18,28H,16-17,19-20H2,1-3H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair