BDBM50077586 4-(2-{[4-(4-Fluoro-phenyl)-4-oxo-butyl]-methyl-amino}-ethoxy)-1,3-dihydro-indol-2-one::CHEMBL60900
SMILES: CN(CCCC(=O)c1ccc(F)cc1)CCOc1cccc2NC(=O)Cc12
InChI Key: InChIKey=IOVXZPKVVVPHDX-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50077586 (4-(2-{[4-(4-Fluoro-phenyl)-4-oxo-butyl]-methyl-ami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranes | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50077586 (4-(2-{[4-(4-Fluoro-phenyl)-4-oxo-butyl]-methyl-ami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranes | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50077586 (4-(2-{[4-(4-Fluoro-phenyl)-4-oxo-butyl]-methyl-ami...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 253 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenates | J Med Chem 42: 2007-20 (1999) Article DOI: 10.1021/jm990023s BindingDB Entry DOI: 10.7270/Q25D8R1W | |||||||||||
More data for this Ligand-Target Pair |