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BDBM50077590 4-{2-[(Biphenyl-4-ylmethyl)-amino]-ethoxy}-7-fluoro-1,3-dihydro-indol-2-one::CHEMBL64798

SMILES: Fc1ccc(OCCNCc2ccc(cc2)-c2ccccc2)c2CC(=O)Nc12

InChI Key: InChIKey=PLXCESBDIJXCGL-UHFFFAOYSA-N

Data: 3 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077590   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50077590
PNG
(4-{2-[(Biphenyl-4-ylmethyl)-amino]-ethoxy}-7-fluor...)
Show SMILES Fc1ccc(OCCNCc2ccc(cc2)-c2ccccc2)c2CC(=O)Nc12
Show InChI InChI=1S/C23H21FN2O2/c24-20-10-11-21(19-14-22(27)26-23(19)20)28-13-12-25-15-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-11,25H,12-15H2,(H,26,27)
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Similars

Article
PubMed
4.80n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranes


J Med Chem 42: 2007-20 (1999)


Article DOI: 10.1021/jm990023s
BindingDB Entry DOI: 10.7270/Q25D8R1W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50077590
PNG
(4-{2-[(Biphenyl-4-ylmethyl)-amino]-ethoxy}-7-fluor...)
Show SMILES Fc1ccc(OCCNCc2ccc(cc2)-c2ccccc2)c2CC(=O)Nc12
Show InChI InChI=1S/C23H21FN2O2/c24-20-10-11-21(19-14-22(27)26-23(19)20)28-13-12-25-15-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-11,25H,12-15H2,(H,26,27)
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Article
PubMed
27n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranes


J Med Chem 42: 2007-20 (1999)


Article DOI: 10.1021/jm990023s
BindingDB Entry DOI: 10.7270/Q25D8R1W
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50077590
PNG
(4-{2-[(Biphenyl-4-ylmethyl)-amino]-ethoxy}-7-fluor...)
Show SMILES Fc1ccc(OCCNCc2ccc(cc2)-c2ccccc2)c2CC(=O)Nc12
Show InChI InChI=1S/C23H21FN2O2/c24-20-10-11-21(19-14-22(27)26-23(19)20)28-13-12-25-15-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-11,25H,12-15H2,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
340n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenates


J Med Chem 42: 2007-20 (1999)


Article DOI: 10.1021/jm990023s
BindingDB Entry DOI: 10.7270/Q25D8R1W
More data for this
Ligand-Target Pair