BDBM50078395 (S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-ethyl)-amide::CHEMBL80368

SMILES: C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O

InChI Key: InChIKey=LOSBOHMHLCTYGM-XKGSQUFQSA-N

Data: 18 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50078395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound human aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Leucine aminopeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Leucyl aminopeptidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Leucine aminopeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Leucyl aminopeptidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro dipeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Prolidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 2 (Rattus norvegicus)	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Activity against membrane bound rat aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound monkey aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against cytosolic Aminopeptidase P from human heart.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro dipeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Prolidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound monkey aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 2 (Rattus norvegicus)	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Activity against membrane bound rat aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against cytosolic Aminopeptidase P from human heart.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 2 (Rattus norvegicus)	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Activity against membrane bound rat aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound human aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound monkey aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound human aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro dipeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Prolidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Leucine aminopeptidase (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Leucyl aminopeptidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50078395 ((S)-1-(2-Hydroxycarbamoyl-cyclohexanecarbonyl)-pyr...) Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCCCC1C(=O)NO)C(N)=O Show InChI InChI=1S/C16H26N4O5/c1-9(13(17)21)18-15(23)12-7-4-8-20(12)16(24)11-6-3-2-5-10(11)14(22)19-25/h9-12,25H,2-8H2,1H3,(H2,17,21)(H,18,23)(H,19,22)/t9-,10?,11?,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against cytosolic Aminopeptidase P from human heart.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair