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SMILES: Nc1nc2c(Oc3ccccc3)c[nH]c2c(=O)[nH]1

InChI Key: InChIKey=NKOQZBQJDRYCNS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50078459   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Purine nucleoside phosphorylase


(Bos taurus (bovine))		BDBM50078459
PNG
(2-Amino-7-phenoxy-3,5-dihydro-pyrrolo[3,2-d]pyrimi...)
Show SMILES Nc1nc2c(Oc3ccccc3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H10N4O2/c13-12-15-9-8(6-14-10(9)11(17)16-12)18-7-4-2-1-3-5-7/h1-6,14H,(H3,13,15,16,17)
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PC sid
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Article
PubMed
n/an/a 41.5n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.

J Med Chem 42: 2422-31 (1999)


Article DOI: 10.1021/jm990037y
BindingDB Entry DOI: 10.7270/Q2CR5SKN
More data for this
Ligand-Target Pair