BDBM50078531 4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxaline-2-carboxylic acid::CHEMBL84283

SMILES: OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F

InChI Key: InChIKey=LKDLBWMHZDTSMM-UHFFFAOYSA-N

Data: 2 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50078531   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50078531 (4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...) Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F Show InChI InChI=1S/C11H5F3N4O3/c12-11(13,14)4-1-2-6-5(3-4)15-9(19)8-16-7(10(20)21)17-18(6)8/h1-3H,(H,15,19)(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita' di Firenze Curated by ChEMBL					Assay Description Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand				J Med Chem 42: 2478-84 (1999) Article DOI: 10.1021/jm981102r BindingDB Entry DOI: 10.7270/Q20K27R0
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50078531 (4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...) Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F Show InChI InChI=1S/C11H5F3N4O3/c12-11(13,14)4-1-2-6-5(3-4)15-9(19)8-16-7(10(20)21)17-18(6)8/h1-3H,(H,15,19)(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Moscow State University Curated by ChEMBL					Assay Description Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA				J Med Chem 46: 4063-9 (2003) Article DOI: 10.1021/jm030833a BindingDB Entry DOI: 10.7270/Q2445KVC
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50078531 (4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...) Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F Show InChI InChI=1S/C11H5F3N4O3/c12-11(13,14)4-1-2-6-5(3-4)15-9(19)8-16-7(10(20)21)17-18(6)8/h1-3H,(H,15,19)(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.18E+3	n/a	n/a	n/a	n/a
Universita' di Firenze Curated by ChEMBL					Assay Description Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...				J Med Chem 42: 2478-84 (1999) Article DOI: 10.1021/jm981102r BindingDB Entry DOI: 10.7270/Q20K27R0
					More data for this Ligand-Target Pair