BDBM50079129 3-(2-Methyl-piperidin-1-yl)-N-{7-[3-(2-methyl-piperidin-1-yl)-propionylamino]-9-oxo-9H-fluoren-2-yl}-propionamide::CHEMBL88257
SMILES: CC1CCCCN1CCC(=O)Nc1ccc2-c3ccc(NC(=O)CCN4CCCCC4C)cc3C(=O)c2c1
InChI Key: InChIKey=WLRLTOOAYKMFCQ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50079129 (3-(2-Methyl-piperidin-1-yl)-N-{7-[3-(2-methyl-pipe...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.20E+10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of telomerase (unknown origin) | Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50079129 (3-(2-Methyl-piperidin-1-yl)-N-{7-[3-(2-methyl-pipe...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibitory activity against telomerase | J Med Chem 42: 2679-84 (1999) Article DOI: 10.1021/jm990084q BindingDB Entry DOI: 10.7270/Q2DF6RX9 | |||||||||||
More data for this Ligand-Target Pair |