BDBM50080787 6-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one::CHEMBL122049

SMILES: Cc1ccc(cc1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1

InChI Key: InChIKey=KHKRYGLBDNZDKR-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50080787   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50080787 (6-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...) Show SMILES Cc1ccc(cc1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1 Show InChI InChI=1S/C21H22N2O2/c1-16-2-6-19(7-3-16)23-12-10-22(11-13-23)15-17-4-8-20-18(14-17)5-9-21(24)25-20/h2-9,14H,10-13,15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Binding affinity using [3H]spiperone displacement from cloned human Dopamine receptor D4.2 expressed in CHO-K1 cells				J Med Chem 42: 3718-25 (1999) Article DOI: 10.1021/jm990266k BindingDB Entry DOI: 10.7270/Q2RN371G
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50080787 (6-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...) Show SMILES Cc1ccc(cc1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1 Show InChI InChI=1S/C21H22N2O2/c1-16-2-6-19(7-3-16)23-12-10-22(11-13-23)15-17-4-8-20-18(14-17)5-9-21(24)25-20/h2-9,14H,10-13,15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Compound was tested for the inhibition of [3H]-thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2				J Med Chem 42: 3718-25 (1999) Article DOI: 10.1021/jm990266k BindingDB Entry DOI: 10.7270/Q2RN371G
					More data for this Ligand-Target Pair