BDBM50081085 1-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-piperazin-1-yl)-2-phenyl-ethanone::CHEMBL87544

SMILES: Nc1cccc(n1)-c1ccc(CCN2CCN(CC2)C(=O)Cc2ccccc2)cc1

InChI Key: InChIKey=OGBDXFPHEQDXMH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50081085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nitric-oxide synthase, brain (Rattus norvegicus (rat))	BDBM50081085 (1-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...) Show SMILES Nc1cccc(n1)-c1ccc(CCN2CCN(CC2)C(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O/c26-24-8-4-7-23(27-24)22-11-9-20(10-12-22)13-14-28-15-17-29(18-16-28)25(30)19-21-5-2-1-3-6-21/h1-12H,13-19H2,(H2,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Groton Curated by ChEMBL					Assay Description Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 9: 2569-72 (1999) BindingDB Entry DOI: 10.7270/Q2BC3XRP
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50081085 (1-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...) Show SMILES Nc1cccc(n1)-c1ccc(CCN2CCN(CC2)C(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O/c26-24-8-4-7-23(27-24)22-11-9-20(10-12-22)13-14-28-15-17-29(18-16-28)25(30)19-21-5-2-1-3-6-21/h1-12H,13-19H2,(H2,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Groton Curated by ChEMBL					Assay Description Inhibitory activity against human neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 9: 2569-72 (1999) BindingDB Entry DOI: 10.7270/Q2BC3XRP
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50081085 (1-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...) Show SMILES Nc1cccc(n1)-c1ccc(CCN2CCN(CC2)C(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O/c26-24-8-4-7-23(27-24)22-11-9-20(10-12-22)13-14-28-15-17-29(18-16-28)25(30)19-21-5-2-1-3-6-21/h1-12H,13-19H2,(H2,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	685	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Groton Curated by ChEMBL					Assay Description Inhibitory activity against human endothelial nitric oxide synthase (eNOS)				Bioorg Med Chem Lett 9: 2569-72 (1999) BindingDB Entry DOI: 10.7270/Q2BC3XRP
					More data for this Ligand-Target Pair