BDBM50081089 CHEMBL315454::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-8-methoxy-2-oxo-3-phenylmethanesulfonylamino-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide; TFA
SMILES: COc1ccc2CC[C@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)N[C@H]3CCCN(C3O)C(N)=N)c2c1
InChI Key: InChIKey=FEHUMILJOHPBKO-GAIPOIILSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen (Homo sapiens (Human)) | BDBM50081089 (CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound against human enzyme plasmin | Bioorg Med Chem Lett 9: 2573-8 (1999) BindingDB Entry DOI: 10.7270/Q26M361R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50081089 (CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound against human enzyme Coagulation factor X | Bioorg Med Chem Lett 9: 2573-8 (1999) BindingDB Entry DOI: 10.7270/Q26M361R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50081089 (CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound against human enzyme Coagulation factor X | Bioorg Med Chem Lett 9: 2573-8 (1999) BindingDB Entry DOI: 10.7270/Q26M361R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin-1 (Homo sapiens (Human)) | BDBM50081089 (CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro evaluation of inhibition of cleavage of the chromogenic substrate by human enzyme trypsin | Bioorg Med Chem Lett 9: 2573-8 (1999) BindingDB Entry DOI: 10.7270/Q26M361R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50081089 (CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Corvas International, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound against human enzyme thrombin | Bioorg Med Chem Lett 9: 2573-8 (1999) BindingDB Entry DOI: 10.7270/Q26M361R | |||||||||||
More data for this Ligand-Target Pair |