BDBM50081214 CHEMBL340493::[(S)-4-((S)-2-Amino-2-mercapto-ethyl)-3-butyl-piperazin-1-yl]-naphthalen-1-yl-methanone
SMILES: CCCC[C@H]1CN(CCN1C[C@@H](N)S)C(=O)c1cccc2ccccc12
InChI Key: InChIKey=YHIHBFWTEDMUPR-PXNSSMCTSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human)) | BDBM50081214 (CHEMBL340493 | [(S)-4-((S)-2-Amino-2-mercapto-ethy...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase | J Med Chem 42: 3779-84 (1999) BindingDB Entry DOI: 10.7270/Q2F47NB1 | |||||||||||
More data for this Ligand-Target Pair |