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SMILES: CCCC[C@H]1CN(CCN1Cc1cnc[nH]1)C(=O)c1cccc2ccccc12

InChI Key: InChIKey=KPFZRSHCCBNZOG-FQEVSTJZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50081220   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50081220
PNG
(CHEMBL125070 | [(S)-3-Butyl-4-(3H-imidazol-4-ylmet...)
Show SMILES CCCC[C@H]1CN(CCN1Cc1cnc[nH]1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O/c1-2-3-9-20-16-27(13-12-26(20)15-19-14-24-17-25-19)23(28)22-11-6-8-18-7-4-5-10-21(18)22/h4-8,10-11,14,17,20H,2-3,9,12-13,15-16H2,1H3,(H,24,25)/t20-/m0/s1
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PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase

J Med Chem 42: 3779-84 (1999)


BindingDB Entry DOI: 10.7270/Q2F47NB1
More data for this
Ligand-Target Pair