BDBM50081444 4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-ylmethyl)-biphenyl-2-sulfonic acid (2-methyl-2-phenyl-propionyl)-amide::CHEMBL314533
SMILES: CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2c3ccccc3CCc3ccccc3C2=O)cc1)c1ccccc1
InChI Key: InChIKey=ACRISRQBBKJCTH-UHFFFAOYSA-N
Data: 8 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Affinity at human EP1 receptor. | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid DP receptor (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Compound was evaluated for its secondary binding affinity to human DP receptors by using Aequorin luminescence-based functional calcium assay | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Compound was evaluated for its secondary binding affinity to human TP receptors by using Aequorin luminescence-based functional calcium assay | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Affinity at human EP3 receptor. | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Affinity at human EP4 receptor. | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human)) | BDBM50081444 (4'-(6-Oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Affinity at human EP2 receptor. | Bioorg Med Chem Lett 9: 2699-704 (1999) BindingDB Entry DOI: 10.7270/Q2HX1BV9 | |||||||||||
More data for this Ligand-Target Pair |