BDBM50082786 3-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-6-methyl-2-oxo-4-m-tolyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester::CHEMBL358489
SMILES: COC(=O)C1=C(C)NC(=O)N(C1c1cccc(C)c1)C(=O)NCCCN1CCC(CC1)(C(=O)OC)c1ccccc1
InChI Key: InChIKey=WPSYNFMKLRQHSU-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50082786 (3-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...) | Reactome pathway KEGG DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description In vitro binding affinity against Alpha-1A adrenergic receptor of human liver microsomes. | J Med Chem 42: 4764-77 (1999) BindingDB Entry DOI: 10.7270/Q2W959W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50082786 (3-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...) | GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes. | J Med Chem 42: 4764-77 (1999) BindingDB Entry DOI: 10.7270/Q2W959W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50082786 (3-[3-(4-Methoxycarbonyl-4-phenyl-piperidin-1-yl)-p...) | Reactome pathway KEGG DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes. | J Med Chem 42: 4764-77 (1999) BindingDB Entry DOI: 10.7270/Q2W959W2 | |||||||||||
More data for this Ligand-Target Pair |