BDBM50083046 5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-isoxazole-3-carboxylic acid::CHEMBL344122

SMILES: Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C

InChI Key: InChIKey=SOHWQOITYAGDRG-UHFFFAOYSA-N

Data: 5 Kd  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50083046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description In vitro binding affinity for Retinoid X receptor RXR alpha				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description Transcriptional activation of Retinoic acid receptor RAR gamma				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description In vitro binding affinity for Retinoid X receptor RXR gamma				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description In vitro binding affinity for Retinoic acid receptor RAR gamma				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description Transcriptional activation of Retinoic acid receptor RAR beta				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description In vitro binding affinity for Retinoic acid receptor RAR alpha				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50083046 (5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Cc1cc2c(cc1-c1cc(no1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C19H23NO3/c1-11-8-13-14(19(4,5)7-6-18(13,2)3)9-12(11)16-10-15(17(21)22)20-23-16/h8-10H,6-7H2,1-5H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description In vitro binding affinity for Retinoic acid receptor RAR beta				J Med Chem 42: 4961-9 (2000) BindingDB Entry DOI: 10.7270/Q24F1PX3
					More data for this Ligand-Target Pair