BDBM50083934 4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid::CHEMBL23545::CHEMBL424806

SMILES: OC(=O)C(=O)CC(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=REKRWOUHJMMFBQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50083934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kynurenine 3-monooxygenase (Rattus norvegicus)	BDBM50083934 (4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...) Show SMILES OC(=O)C(=O)CC(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C10H7ClO4/c11-7-3-1-6(2-4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver				J Med Chem 43: 123-7 (2000) BindingDB Entry DOI: 10.7270/Q2RX9B9B
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM50083934 (4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...) Show SMILES OC(=O)C(=O)CC(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C10H7ClO4/c11-7-3-1-6(2-4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition of Flap endonuclease-1				Bioorg Med Chem Lett 14: 4915-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF
					More data for this Ligand-Target Pair
DNA excision repair protein ERCC-5 (Homo sapiens (Human))	BDBM50083934 (4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...) Show SMILES OC(=O)C(=O)CC(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C10H7ClO4/c11-7-3-1-6(2-4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition of Xeroderma pigmentosum G				Bioorg Med Chem Lett 14: 4915-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF
					More data for this Ligand-Target Pair