BDBM50084728 4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-hydroxyamide 1-[(3-methoxy-phenyl)-amide]::CHEMBL419430

SMILES: COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1

InChI Key: InChIKey=GUHYZHHGWPARCR-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50084728   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-7 (MMP-7)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Missouri-St. Louis Curated by ChEMBL					Assay Description Binding affinity towards matrix metalloprotease-3				J Med Chem 44: 3849-55 (2001) BindingDB Entry DOI: 10.7270/Q2ZK5HWX
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-1 (MMP-1)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50084728 (4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)Nc1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O7S/c1-30-15-6-8-17(9-7-15)32(28,29)24-11-10-23(13-18(24)19(25)22-27)20(26)21-14-4-3-5-16(12-14)31-2/h3-9,12,18,27H,10-11,13H2,1-2H3,(H,21,26)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-3 (MMP-3)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair