BDBM50084738 4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-methoxy-benzenesulfonyl)-piperazine-2-carboxylic acid hydroxyamide::CHEMBL126044

SMILES: COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C

InChI Key: InChIKey=HWRVCRDVLWYPOY-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50084738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-1 (MMP-1)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Missouri-St. Louis Curated by ChEMBL					Assay Description Binding affinity towards matrix metalloprotease-3				J Med Chem 44: 3849-55 (2001) BindingDB Entry DOI: 10.7270/Q2ZK5HWX
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-3 (MMP-3)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-7 (MMP-7)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50084738 (4-(2-Amino-4-methyl-thiazole-5-sulfonyl)-1-(4-meth...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)S(=O)(=O)c1sc(N)nc1C Show InChI InChI=1S/C16H21N5O7S3/c1-10-15(29-16(17)18-10)31(26,27)20-7-8-21(13(9-20)14(22)19-23)30(24,25)12-5-3-11(28-2)4-6-12/h3-6,13,23H,7-9H2,1-2H3,(H2,17,18)(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)				J Med Chem 43: 369-80 (2000) BindingDB Entry DOI: 10.7270/Q2J965M3
					More data for this Ligand-Target Pair