BDBM50084848 BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinoliniumamine)::Bis-quinolinium cyclophane analogue::CHEMBL446445::UCL-1530

SMILES: C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21

InChI Key: InChIKey=NWUHMRZECZQMJQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50084848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (KCa2.2) (Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair