BDBM50085970 CHEMBL7318::[2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-dimethyl-amine::[2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-dimethyl-amine (C2H2O4)::[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]dimethylamine, 5

SMILES: COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1

InChI Key: InChIKey=VSGPGYWZVPDDSK-UHFFFAOYSA-N

Data: 16 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50085970   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		20	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Virginia Commonwealth University					Assay Description The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using...				Medicinal Chemistry Research 14: 1-18 (2005) BindingDB Entry DOI: 10.7270/Q2NG4P78
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity against 5 Hydroxy tryptamine 6 receptor				Bioorg Med Chem Lett 15: 1707-11 (2005) Article DOI: 10.1016/j.bmcl.2005.01.031 BindingDB Entry DOI: 10.7270/Q2D21ZBG
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor				J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...				J Med Chem 58: 7901-12 (2015) BindingDB Entry DOI: 10.7270/Q2M90BGQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity for human 5-hydroxytryptamine 6 receptor				J Med Chem 48: 4216-9 (2005) Checked by Author Article DOI: 10.1021/jm050247c BindingDB Entry DOI: 10.7270/Q2736SD0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radio...				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	675	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2C receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human human 5-hydroxytryptamine 1A receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human serotonin transporter				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 5A receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human NET(norepinephrine) transporter				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 | [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor				J Med Chem 43: 1011-8 (2000) BindingDB Entry DOI: 10.7270/Q2CF9PBP
					More data for this Ligand-Target Pair