BDBM50086497 3-(4-Chloro-phenyl)-5-fluoro-1-(4-methoxy-phenyl)-4,5,6,7-tetrahydro-1H-indazole::CHEMBL347688
SMILES: COc1ccc(cc1)-n1nc(c2CC(F)CCc12)-c1ccc(Cl)cc1
InChI Key: InChIKey=OUWFYTHABPBKTA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50086497 (3-(4-Chloro-phenyl)-5-fluoro-1-(4-methoxy-phenyl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2 | Bioorg Med Chem Lett 10: 601-4 (2000) BindingDB Entry DOI: 10.7270/Q2TH8KWZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50086497 (3-(4-Chloro-phenyl)-5-fluoro-1-(4-methoxy-phenyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2 | Bioorg Med Chem Lett 10: 601-4 (2000) BindingDB Entry DOI: 10.7270/Q2TH8KWZ | |||||||||||
More data for this Ligand-Target Pair |