BDBM50087066 CHEMBL281543::N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(4-morpholin-4-yl-butyl)-pyrido[3,2-d]pyrimidin-6-yl]-acrylamide

SMILES: Fc1ccc(Nc2ncnc3cc(CCCCN4CCOCC4)c(NC(=O)C=C)nc23)cc1Cl

InChI Key: InChIKey=VHRIFFSWPSMYNR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50087066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50087066 (CHEMBL281543 | N-[4-(3-Chloro-4-fluoro-phenylamino...) Show SMILES Fc1ccc(Nc2ncnc3cc(CCCCN4CCOCC4)c(NC(=O)C=C)nc23)cc1Cl Show InChI InChI=1S/C24H26ClFN6O2/c1-2-21(33)30-23-16(5-3-4-8-32-9-11-34-12-10-32)13-20-22(31-23)24(28-15-27-20)29-17-6-7-19(26)18(25)14-17/h2,6-7,13-15H,1,3-5,8-12H2,(H,27,28,29)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblotting				J Med Chem 43: 1380-97 (2001) BindingDB Entry DOI: 10.7270/Q2H13179
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50087066 (CHEMBL281543 | N-[4-(3-Chloro-4-fluoro-phenylamino...) Show SMILES Fc1ccc(Nc2ncnc3cc(CCCCN4CCOCC4)c(NC(=O)C=C)nc23)cc1Cl Show InChI InChI=1S/C24H26ClFN6O2/c1-2-21(33)30-23-16(5-3-4-8-32-9-11-34-12-10-32)13-20-22(31-23)24(28-15-27-20)29-17-6-7-19(26)18(25)14-17/h2,6-7,13-15H,1,3-5,8-12H2,(H,27,28,29)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...				J Med Chem 43: 1380-97 (2001) BindingDB Entry DOI: 10.7270/Q2H13179
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50087066 (CHEMBL281543 | N-[4-(3-Chloro-4-fluoro-phenylamino...) Show SMILES Fc1ccc(Nc2ncnc3cc(CCCCN4CCOCC4)c(NC(=O)C=C)nc23)cc1Cl Show InChI InChI=1S/C24H26ClFN6O2/c1-2-21(33)30-23-16(5-3-4-8-32-9-11-34-12-10-32)13-20-22(31-23)24(28-15-27-20)29-17-6-7-19(26)18(25)14-17/h2,6-7,13-15H,1,3-5,8-12H2,(H,27,28,29)(H,30,31,33)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cells				J Med Chem 43: 1380-97 (2001) BindingDB Entry DOI: 10.7270/Q2H13179
					More data for this Ligand-Target Pair