BDBM50087074 CHEMBL32079::N-{4-(3-Chloro-4-fluoro-phenylamino)-7-[2-(4-hydroxy-butoxy)-ethoxy]-quinazolin-6-yl}-acrylamide
SMILES: OCCCCOCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
InChI Key: InChIKey=HVRIYPDAXABTLC-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50087074 (CHEMBL32079 | N-{4-(3-Chloro-4-fluoro-phenylamino)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland Curated by ChEMBL | Assay Description Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm... | J Med Chem 43: 1380-97 (2001) BindingDB Entry DOI: 10.7270/Q2H13179 | |||||||||||
More data for this Ligand-Target Pair |