BDBM50087441 CHEMBL3426629

SMILES: NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1ccc(CC(O)=O)cc1)C(=O)Nc1ccncc1F

InChI Key: InChIKey=KLTXHROXPUSIPD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50087441   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50087441 (CHEMBL3426629) Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1ccc(CC(O)=O)cc1)C(=O)Nc1ccncc1F Show InChI InChI=1S/C28H23FN4O4/c29-24-16-31-11-10-25(24)33-28(37)20-6-7-21(15-30)23(14-20)18-2-1-3-19(13-18)27(36)32-22-8-4-17(5-9-22)12-26(34)35/h1-11,13-14,16H,12,15,30H2,(H,32,36)(H,34,35)(H,31,33,37)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Agoralaan Abis Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...				J Med Chem 58: 4309-24 (2015) Article DOI: 10.1021/acs.jmedchem.5b00308 BindingDB Entry DOI: 10.7270/Q2H41T4R
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