BDBM50087693 1-Phenyl-8-(4-propyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL166445

SMILES: CCC[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key: InChIKey=NHTGUVBHHDMIOT-KDURUIRLSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087693   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin/Orphanin FQ, NOP receptor (RAT)	BDBM50087693 (1-Phenyl-8-(4-propyl-cyclohexyl)-1,3,8-triaza-spir...) Show SMILES CCC[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |wU:6.9,3.2,(1.92,-2.67,;3.46,-2.68,;4.23,-4.01,;5.77,-4.02,;6.54,-2.69,;8.08,-2.69,;8.83,-4.02,;8.08,-5.35,;6.54,-5.35,;10.37,-4.02,;11.14,-2.68,;12.68,-2.67,;13.45,-4.01,;12.68,-5.34,;11.14,-5.34,;14.33,-5.26,;15.8,-4.79,;15.8,-3.25,;14.36,-2.76,;13.87,-1.31,;13.87,-6.7,;12.35,-7.03,;11.88,-8.49,;12.91,-9.64,;14.43,-9.32,;14.89,-7.85,)| Show InChI InChI=1S/C22H33N3O/c1-2-6-18-9-11-19(12-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)20-7-4-3-5-8-20/h3-5,7-8,18-19H,2,6,9-17H2,1H3,(H,23,26)/t18-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1				Bioorg Med Chem Lett 10: 831-4 (2000) BindingDB Entry DOI: 10.7270/Q2N29XG2
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50087693 (1-Phenyl-8-(4-propyl-cyclohexyl)-1,3,8-triaza-spir...) Show SMILES CCC[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |wU:6.9,3.2,(1.92,-2.67,;3.46,-2.68,;4.23,-4.01,;5.77,-4.02,;6.54,-2.69,;8.08,-2.69,;8.83,-4.02,;8.08,-5.35,;6.54,-5.35,;10.37,-4.02,;11.14,-2.68,;12.68,-2.67,;13.45,-4.01,;12.68,-5.34,;11.14,-5.34,;14.33,-5.26,;15.8,-4.79,;15.8,-3.25,;14.36,-2.76,;13.87,-1.31,;13.87,-6.7,;12.35,-7.03,;11.88,-8.49,;12.91,-9.64,;14.43,-9.32,;14.89,-7.85,)| Show InChI InChI=1S/C22H33N3O/c1-2-6-18-9-11-19(12-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)20-7-4-3-5-8-20/h3-5,7-8,18-19H,2,6,9-17H2,1H3,(H,23,26)/t18-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the...				Bioorg Med Chem Lett 10: 831-4 (2000) BindingDB Entry DOI: 10.7270/Q2N29XG2
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM50087693 (1-Phenyl-8-(4-propyl-cyclohexyl)-1,3,8-triaza-spir...) Show SMILES CCC[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |wU:6.9,3.2,(1.92,-2.67,;3.46,-2.68,;4.23,-4.01,;5.77,-4.02,;6.54,-2.69,;8.08,-2.69,;8.83,-4.02,;8.08,-5.35,;6.54,-5.35,;10.37,-4.02,;11.14,-2.68,;12.68,-2.67,;13.45,-4.01,;12.68,-5.34,;11.14,-5.34,;14.33,-5.26,;15.8,-4.79,;15.8,-3.25,;14.36,-2.76,;13.87,-1.31,;13.87,-6.7,;12.35,-7.03,;11.88,-8.49,;12.91,-9.64,;14.43,-9.32,;14.89,-7.85,)| Show InChI InChI=1S/C22H33N3O/c1-2-6-18-9-11-19(12-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)20-7-4-3-5-8-20/h3-5,7-8,18-19H,2,6,9-17H2,1H3,(H,23,26)/t18-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the...				Bioorg Med Chem Lett 10: 831-4 (2000) BindingDB Entry DOI: 10.7270/Q2N29XG2
					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM50087693 (1-Phenyl-8-(4-propyl-cyclohexyl)-1,3,8-triaza-spir...) Show SMILES CCC[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |wU:6.9,3.2,(1.92,-2.67,;3.46,-2.68,;4.23,-4.01,;5.77,-4.02,;6.54,-2.69,;8.08,-2.69,;8.83,-4.02,;8.08,-5.35,;6.54,-5.35,;10.37,-4.02,;11.14,-2.68,;12.68,-2.67,;13.45,-4.01,;12.68,-5.34,;11.14,-5.34,;14.33,-5.26,;15.8,-4.79,;15.8,-3.25,;14.36,-2.76,;13.87,-1.31,;13.87,-6.7,;12.35,-7.03,;11.88,-8.49,;12.91,-9.64,;14.43,-9.32,;14.89,-7.85,)| Show InChI InChI=1S/C22H33N3O/c1-2-6-18-9-11-19(12-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)20-7-4-3-5-8-20/h3-5,7-8,18-19H,2,6,9-17H2,1H3,(H,23,26)/t18-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibition against binding of radioligand [Ile5,6-3H]-deltorphin to membrane from baby hamster kidney cells infected with forest virus encoding the ...				Bioorg Med Chem Lett 10: 831-4 (2000) BindingDB Entry DOI: 10.7270/Q2N29XG2
					More data for this Ligand-Target Pair