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BDBM50087701 8-(4-tert-Butyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL354163

SMILES: CC(C)(C)[C@H]1CC[C@@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key: InChIKey=OYFATNWHESZHAW-WGSAOQKQSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50087701   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nociceptin/Orphanin FQ, NOP receptor


(RAT)		BDBM50087701
PNG
(8-(4-tert-Butyl-cyclohexyl)-1-phenyl-1,3,8-triaza-...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |wU:7.10,wD:4.3,(3.06,-2.68,;3.83,-4.01,;3.06,-5.35,;2.29,-4,;5.37,-4.02,;6.14,-5.35,;7.7,-5.35,;8.45,-4.02,;7.68,-2.69,;6.14,-2.69,;9.99,-4.02,;10.76,-2.68,;12.3,-2.67,;13.05,-4.01,;12.3,-5.34,;10.76,-5.34,;13.95,-5.26,;15.42,-4.79,;15.42,-3.25,;13.96,-2.76,;13.49,-1.31,;13.49,-6.7,;14.51,-7.85,;14.03,-9.32,;12.53,-9.64,;11.5,-8.49,;11.97,-7.03,)|
Show InChI InChI=1S/C23H35N3O/c1-22(2,3)18-9-11-19(12-10-18)25-15-13-23(14-16-25)21(27)24-17-26(23)20-7-5-4-6-8-20/h4-8,18-19H,9-17H2,1-3H3,(H,24,27)/t18-,19-
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PubMed
 12n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1

Bioorg Med Chem Lett 10: 831-4 (2000)


BindingDB Entry DOI: 10.7270/Q2N29XG2
More data for this
Ligand-Target Pair