BDBM50088297 CHEMBL3427748

SMILES: NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=OQZPEYDZBJDMCK-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50088297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assay				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assay				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of HDAC8 (unknown origin)				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 2 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin)				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin)				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50088297 (CHEMBL3427748) Show SMILES NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N3O/c15-10-5-4-7(6-11(10)16)12-8-2-1-3-9(14(17)20)13(8)19-18-12/h4-6,9H,1-3H2,(H2,17,20)(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin)				Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0
					More data for this Ligand-Target Pair