BDBM50089295 1-(5-(4-nitrophenoxy)pentyl)pyrrolidine::1-[5-(4-Nitro-phenoxy)-pentyl]-pyrrolidine::1-[5-(4-Nitro-phenoxy)-pentyl]-pyrrolidine(UCL1972)::CHEMBL289855::UCL-1972
SMILES: [O-][N+](=O)c1ccc(OCCCCCN2CCCC2)cc1
InChI Key: InChIKey=ITOJPDNONZGUKB-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (GUINEA PIG) | BDBM50089295 (1-(5-(4-nitrophenoxy)pentyl)pyrrolidine | 1-[5-(4-...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The James Black Foundation Curated by ChEMBL | Assay Description In vitro binding affinity of the compound towards histamine H3 receptor was determined in guinea-pig cerebral cortex using [3H]-(R)-alpha-methylhista... | J Med Chem 43: 2362-70 (2000) BindingDB Entry DOI: 10.7270/Q2WS8SGF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50089295 (1-(5-(4-nitrophenoxy)pentyl)pyrrolidine | 1-[5-(4-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description In vivo binding affinity was determined by measuring the displacement curves of [125I]iodoproxyfan in human Histamine H3 receptor antagonist with rel... | J Med Chem 46: 1523-30 (2003) Article DOI: 10.1021/jm021084k BindingDB Entry DOI: 10.7270/Q2C24X5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50089295 (1-(5-(4-nitrophenoxy)pentyl)pyrrolidine | 1-[5-(4-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Binding affinity to rat histamine H3 receptor | Bioorg Med Chem Lett 19: 903-7 (2009) Article DOI: 10.1016/j.bmcl.2008.11.114 BindingDB Entry DOI: 10.7270/Q2X63MTD | |||||||||||
More data for this Ligand-Target Pair |