BDBM50090093 CHEMBL3581540::US9216988, 18

SMILES: CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2)c(F)c1

InChI Key: InChIKey=JPZKKUXZHNDSOF-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50090093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50090093 (CHEMBL3581540 | US9216988, 18) Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2)c(F)c1 Show InChI InChI=1S/C23H27ClFN3O3S/c1-17(29)26-10-12-27(13-11-26)21-9-8-18(23(25)15-21)16-28(20-5-3-6-20)32(30,31)22-7-2-4-19(24)14-22/h2,4,7-9,14-15,20H,3,5-6,10-13,16H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.4	n/a
Genentech, Inc. US Patent					Assay Description On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...				US Patent US9216988 (2015) BindingDB Entry DOI: 10.7270/Q2TB15QC
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50090093 (CHEMBL3581540 | US9216988, 18) Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2)c(F)c1 Show InChI InChI=1S/C23H27ClFN3O3S/c1-17(29)26-10-12-27(13-11-26)21-9-8-18(23(25)15-21)16-28(20-5-3-6-20)32(30,31)22-7-2-4-19(24)14-22/h2,4,7-9,14-15,20H,3,5-6,10-13,16H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as activa...				ACS Med Chem Lett 6: 276-81 (2015) Article DOI: 10.1021/ml500420y BindingDB Entry DOI: 10.7270/Q2TT4SPB
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50090093 (CHEMBL3581540 | US9216988, 18) Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2)c(F)c1 Show InChI InChI=1S/C23H27ClFN3O3S/c1-17(29)26-10-12-27(13-11-26)21-9-8-18(23(25)15-21)16-28(20-5-3-6-20)32(30,31)22-7-2-4-19(24)14-22/h2,4,7-9,14-15,20H,3,5-6,10-13,16H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...				ACS Med Chem Lett 6: 276-81 (2015) Article DOI: 10.1021/ml500420y BindingDB Entry DOI: 10.7270/Q2TT4SPB
					More data for this Ligand-Target Pair