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BDBM50090410 4-[Methyl-(3-methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-amino]-2-thiophen-2-yl-pyrimidine-5-carboxylic acid ethyl ester::CHEMBL42547::ethyl 4-(methyl(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-yl)amino)-2-(thiophen-2-yl)pyrimidine-5-carboxylate

SMILES: CCOC(=O)c1cnc(nc1N(C)N1C(=O)C=C(C)C1=O)-c1cccs1

InChI Key: InChIKey=YZVLYVMNCAIILW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50090410   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene c-JUN/protein c-fos


(Homo sapiens (Human))
BDBM50090410
PNG
(4-[Methyl-(3-methyl-2,5-dioxo-2,5-dihydro-pyrrol-1...)
Show SMILES CCOC(=O)c1cnc(nc1N(C)N1C(=O)C=C(C)C1=O)-c1cccs1 |t:17|
Show InChI InChI=1S/C17H16N4O4S/c1-4-25-17(24)11-9-18-14(12-6-5-7-26-12)19-15(11)20(3)21-13(22)8-10(2)16(21)23/h5-9H,4H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells


Bioorg Med Chem Lett 10: 1645-8 (2000)


BindingDB Entry DOI: 10.7270/Q2F190XH
More data for this
Ligand-Target Pair