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SMILES: Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1ccc2[nH]ncc2c1

InChI Key: InChIKey=OHFQSPNVOAYQQX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50091866   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50091866
PNG
(CHEMBL3582389)
Show SMILES Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H12F2N4O2S/c21-17-6-8-19(26-29(27,28)15-2-1-9-23-12-15)20(22)16(17)5-3-13-4-7-18-14(10-13)11-24-25-18/h1-2,4,6-12,26H,(H,24,25)
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Similars
Article
PubMed
n/an/a 4.31E+3n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL


Assay Description
Inhibition of human recombinant B-Raf V600E mutant by FRET-based Z'-lyte assay

ACS Med Chem Lett 6: 543-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00039
BindingDB Entry DOI: 10.7270/Q26W9CT5
More data for this
Ligand-Target Pair