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SMILES: CC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N

InChI Key: InChIKey=CRZFJHYKXXQOID-JOCHJYFZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092361   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092361
PNG
(4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4...)
Show SMILES CC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C23H23N5O/c1-17(29)28-13-20-9-19(11-24)7-8-23(20)27(14-21-12-25-16-26-21)15-22(28)10-18-5-3-2-4-6-18/h2-9,12,16,22H,10,13-15H2,1H3,(H,25,26)/t22-/m1/s1
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PubMed
n/an/a 8.75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair