BDBM50092475 CHEMBL3586185

SMILES: Clc1ccc(\C=C2\SC(=NC2=O)N2CCC[C@H]2C(=O)Nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2)cc1

InChI Key: InChIKey=NOQCGSHSQWSZGC-ZHIQAQTNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092475   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50092475 (CHEMBL3586185) Show SMILES Clc1ccc(\C=C2\SC(=NC2=O)N2CCC[C@H]2C(=O)Nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2)cc1 |r,c:8| Show InChI InChI=1S/C29H22Cl2N6O2S/c30-18-8-6-17(7-9-18)13-25-28(39)36-29(40-25)37-12-2-5-24(37)27(38)35-21-10-11-23-22(15-21)26(33-16-32-23)34-20-4-1-3-19(31)14-20/h1,3-4,6-11,13-16,24H,2,5,12H2,(H,35,38)(H,32,33,34)/b25-13+/t24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Soochow University Curated by ChEMBL					Assay Description Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry				Bioorg Med Chem 23: 3221-7 (2015) Article DOI: 10.1016/j.bmc.2015.04.065 BindingDB Entry DOI: 10.7270/Q2DF6SXQ
					More data for this Ligand-Target Pair