Found 5 hits for monomerid = 50092638 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092638
(CHEMBL3586353)Show SMILES Clc1cc(cc2CN(Cc3cccnc3)CCOc12)-c1csc2ccccc12 Show InChI InChI=1S/C79H100FN17O19S2/c1-42(85-64(102)37-82)67(103)94-61-40-117-118-41-62(79(115)116)95-75(111)60(39-98)93-78(114)66(44(3)100)97-74(110)57(33-47-21-11-6-12-22-47)92-77(113)65(43(2)99)96-73(109)56(34-48-26-28-50(80)29-27-48)89-71(107)58(35-49-38-84-52-24-14-13-23-51(49)52)90-70(106)55(32-46-19-9-5-10-20-46)87-69(105)54(31-45-17-7-4-8-18-45)88-72(108)59(36-63(83)101)91-68(104)53(86-76(61)112)25-15-16-30-81/h4-14,17-24,26-29,38,42-44,53-62,65-66,84,98-100H,15-16,25,30-37,39-41,81-82H2,1-3H3,(H2,83,101)(H,85,102)(H,86,112)(H,87,105)(H,88,108)(H,89,107)(H,90,106)(H,91,104)(H,92,113)(H,93,114)(H,94,103)(H,95,111)(H,96,109)(H,97,110)(H,115,116)/t42?,43?,44?,53-,54-,55-,56-,57-,58?,59-,60-,61-,62+,65-,66-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092638
(CHEMBL3586353)Show SMILES Clc1cc(cc2CN(Cc3cccnc3)CCOc12)-c1csc2ccccc12 Show InChI InChI=1S/C79H100FN17O19S2/c1-42(85-64(102)37-82)67(103)94-61-40-117-118-41-62(79(115)116)95-75(111)60(39-98)93-78(114)66(44(3)100)97-74(110)57(33-47-21-11-6-12-22-47)92-77(113)65(43(2)99)96-73(109)56(34-48-26-28-50(80)29-27-48)89-71(107)58(35-49-38-84-52-24-14-13-23-51(49)52)90-70(106)55(32-46-19-9-5-10-20-46)87-69(105)54(31-45-17-7-4-8-18-45)88-72(108)59(36-63(83)101)91-68(104)53(86-76(61)112)25-15-16-30-81/h4-14,17-24,26-29,38,42-44,53-62,65-66,84,98-100H,15-16,25,30-37,39-41,81-82H2,1-3H3,(H2,83,101)(H,85,102)(H,86,112)(H,87,105)(H,88,108)(H,89,107)(H,90,106)(H,91,104)(H,92,113)(H,93,114)(H,94,103)(H,95,111)(H,96,109)(H,97,110)(H,115,116)/t42?,43?,44?,53-,54-,55-,56-,57-,58?,59-,60-,61-,62+,65-,66-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype (EP1)
(Homo sapiens (Human)) | BDBM50092638
(CHEMBL3586353)Show SMILES Clc1cc(cc2CN(Cc3cccnc3)CCOc12)-c1csc2ccccc12 Show InChI InChI=1S/C79H100FN17O19S2/c1-42(85-64(102)37-82)67(103)94-61-40-117-118-41-62(79(115)116)95-75(111)60(39-98)93-78(114)66(44(3)100)97-74(110)57(33-47-21-11-6-12-22-47)92-77(113)65(43(2)99)96-73(109)56(34-48-26-28-50(80)29-27-48)89-71(107)58(35-49-38-84-52-24-14-13-23-51(49)52)90-70(106)55(32-46-19-9-5-10-20-46)87-69(105)54(31-45-17-7-4-8-18-45)88-72(108)59(36-63(83)101)91-68(104)53(86-76(61)112)25-15-16-30-81/h4-14,17-24,26-29,38,42-44,53-62,65-66,84,98-100H,15-16,25,30-37,39-41,81-82H2,1-3H3,(H2,83,101)(H,85,102)(H,86,112)(H,87,105)(H,88,108)(H,89,107)(H,90,106)(H,91,104)(H,92,113)(H,93,114)(H,94,103)(H,95,111)(H,96,109)(H,97,110)(H,115,116)/t42?,43?,44?,53-,54-,55-,56-,57-,58?,59-,60-,61-,62+,65-,66-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-PGE2 from human EP1 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50092638
(CHEMBL3586353)Show SMILES Clc1cc(cc2CN(Cc3cccnc3)CCOc12)-c1csc2ccccc12 Show InChI InChI=1S/C79H100FN17O19S2/c1-42(85-64(102)37-82)67(103)94-61-40-117-118-41-62(79(115)116)95-75(111)60(39-98)93-78(114)66(44(3)100)97-74(110)57(33-47-21-11-6-12-22-47)92-77(113)65(43(2)99)96-73(109)56(34-48-26-28-50(80)29-27-48)89-71(107)58(35-49-38-84-52-24-14-13-23-51(49)52)90-70(106)55(32-46-19-9-5-10-20-46)87-69(105)54(31-45-17-7-4-8-18-45)88-72(108)59(36-63(83)101)91-68(104)53(86-76(61)112)25-15-16-30-81/h4-14,17-24,26-29,38,42-44,53-62,65-66,84,98-100H,15-16,25,30-37,39-41,81-82H2,1-3H3,(H2,83,101)(H,85,102)(H,86,112)(H,87,105)(H,88,108)(H,89,107)(H,90,106)(H,91,104)(H,92,113)(H,93,114)(H,94,103)(H,95,111)(H,96,109)(H,97,110)(H,115,116)/t42?,43?,44?,53-,54-,55-,56-,57-,58?,59-,60-,61-,62+,65-,66-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50092638
(CHEMBL3586353)Show SMILES Clc1cc(cc2CN(Cc3cccnc3)CCOc12)-c1csc2ccccc12 Show InChI InChI=1S/C79H100FN17O19S2/c1-42(85-64(102)37-82)67(103)94-61-40-117-118-41-62(79(115)116)95-75(111)60(39-98)93-78(114)66(44(3)100)97-74(110)57(33-47-21-11-6-12-22-47)92-77(113)65(43(2)99)96-73(109)56(34-48-26-28-50(80)29-27-48)89-71(107)58(35-49-38-84-52-24-14-13-23-51(49)52)90-70(106)55(32-46-19-9-5-10-20-46)87-69(105)54(31-45-17-7-4-8-18-45)88-72(108)59(36-63(83)101)91-68(104)53(86-76(61)112)25-15-16-30-81/h4-14,17-24,26-29,38,42-44,53-62,65-66,84,98-100H,15-16,25,30-37,39-41,81-82H2,1-3H3,(H2,83,101)(H,85,102)(H,86,112)(H,87,105)(H,88,108)(H,89,107)(H,90,106)(H,91,104)(H,92,113)(H,93,114)(H,94,103)(H,95,111)(H,96,109)(H,97,110)(H,115,116)/t42?,43?,44?,53-,54-,55-,56-,57-,58?,59-,60-,61-,62+,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-PGE2 from human EP3 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this Ligand-Target Pair | |