Found 3 hits for monomerid = 50092809 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50092809
(CHEMBL3586413)Show SMILES [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc2ccc(Cl)cc2s1)C(=O)c1c(OC)cccc1OC |r| Show InChI InChI=1S/C22H22ClN3O3S/c1-28-17-4-3-5-18(29-2)20(17)21(27)25-9-13-11-26(12-14(13)10-25)22-24-16-7-6-15(23)8-19(16)30-22/h3-8,13-14H,9-12H2,1-2H3/t13-,14+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin A from OX1 receptor (unknown origin) expressed in CHOK1 cells after 90 to 120 mins by scintillation counting analysis |
J Med Chem 58: 5620-36 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00742
BindingDB Entry DOI: 10.7270/Q2QR4ZWG |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50092809
(CHEMBL3586413)Show SMILES [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc2ccc(Cl)cc2s1)C(=O)c1c(OC)cccc1OC |r| Show InChI InChI=1S/C22H22ClN3O3S/c1-28-17-4-3-5-18(29-2)20(17)21(27)25-9-13-11-26(12-14(13)10-25)22-24-16-7-6-15(23)8-19(16)30-22/h3-8,13-14H,9-12H2,1-2H3/t13-,14+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to rat OX2 receptor |
J Med Chem 58: 5620-36 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00742
BindingDB Entry DOI: 10.7270/Q2QR4ZWG |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50092809
(CHEMBL3586413)Show SMILES [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc2ccc(Cl)cc2s1)C(=O)c1c(OC)cccc1OC |r| Show InChI InChI=1S/C22H22ClN3O3S/c1-28-17-4-3-5-18(29-2)20(17)21(27)25-9-13-11-26(12-14(13)10-25)22-24-16-7-6-15(23)8-19(16)30-22/h3-8,13-14H,9-12H2,1-2H3/t13-,14+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human OX1 receptor |
J Med Chem 58: 5620-36 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00742
BindingDB Entry DOI: 10.7270/Q2QR4ZWG |
More data for this
Ligand-Target Pair | |
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