BindingDB PrimarySearch

BDBM50094024 (+/-) Propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl)-propyl]-amide::CHEMBL435582::propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl)-propyl]-amide

SMILES: CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N

InChI Key: InChIKey=HOQAVGZLYRYHSO-UHFFFAOYSA-N

Data: 11 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50094024
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
NPS Allelix Corporation Curated by ChEMBL					Assay Description Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.				J Med Chem 45: 2101-11 (2002) BindingDB Entry DOI: 10.7270/Q20R9NRB
NPS Allelix Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	559	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
Lilly S.A. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GRIA2 (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
Lilly S.A. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
Lilly S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
Lilly S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
NPS Allelix Corporation Curated by ChEMBL					Assay Description Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells				J Med Chem 43: 4354-8 (2000) BindingDB Entry DOI: 10.7270/Q2R2123P
NPS Allelix Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at GluR2 receptor				J Med Chem 53: 7271-9 (2010) Article DOI: 10.1021/jm1000419 BindingDB Entry DOI: 10.7270/Q2W0965T
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GluR3 expressed in HEK cells				J Med Chem 53: 7271-9 (2010) Article DOI: 10.1021/jm1000419 BindingDB Entry DOI: 10.7270/Q2W0965T
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GRIA1 (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.65E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GluR1 expressed in HEK cells				J Med Chem 53: 7271-9 (2010) Article DOI: 10.1021/jm1000419 BindingDB Entry DOI: 10.7270/Q2W0965T
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GRIA2 (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GluR2 flop expressed in HEK cells				J Med Chem 53: 7271-9 (2010) Article DOI: 10.1021/jm1000419 BindingDB Entry DOI: 10.7270/Q2W0965T
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50094024 ((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GluR4 expressed in HEK293 cells				J Med Chem 53: 7271-9 (2010) Article DOI: 10.1021/jm1000419 BindingDB Entry DOI: 10.7270/Q2W0965T
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair