BDBM50095236 6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile::CHEMBL97714

SMILES: COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1

InChI Key: InChIKey=JVSMBUXACUSJML-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095236   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) (Homo sapiens (Human))	BDBM50095236 (6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...) Show SMILES COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-22-21(13-20)23(16(14-24)15-25-22)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA				Bioorg Med Chem Lett 10: 2825-8 (2000) BindingDB Entry DOI: 10.7270/Q22N51J8
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50095236 (6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...) Show SMILES COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-22-21(13-20)23(16(14-24)15-25-22)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA				Bioorg Med Chem Lett 10: 2825-8 (2000) BindingDB Entry DOI: 10.7270/Q22N51J8
					More data for this Ligand-Target Pair