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BDBM50095287 CHEMBL3085880

SMILES: Nc1nc2CC[C@@H](Cc2s1)NC(=O)c1cc(Br)c(Br)[nH]1

InChI Key: InChIKey=PHOOWFUDCZCEGK-UHFFFAOYSA-N

Data: 5 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50095287
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluorescence based DNA...				J Med Chem 58: 5501-21 (2015) Article DOI: 10.1021/acs.jmedchem.5b00489 BindingDB Entry DOI: 10.7270/Q2MP551H
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Binding affinity to Escherichia coli DNA gyrase subunit B N-terminal 24 kDa domain by SPR assay				J Med Chem 58: 5501-21 (2015) Article DOI: 10.1021/acs.jmedchem.5b00489 BindingDB Entry DOI: 10.7270/Q2MP551H
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 3 subunit alpha (Homo sapiens (Human))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Modulation of human Nav1.3 by automated patch clamp electrophysiology assay				Eur J Med Chem 70: 154-64 (2013) Article DOI: 10.1016/j.ejmech.2013.07.034 BindingDB Entry DOI: 10.7270/Q2DR2ZF3
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Modulation of human Nav1.5 by automated patch clamp electrophysiology assay				Eur J Med Chem 70: 154-64 (2013) Article DOI: 10.1016/j.ejmech.2013.07.034 BindingDB Entry DOI: 10.7270/Q2DR2ZF3
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Modulation of human Nav1.4 by automated patch clamp electrophysiology assay				Eur J Med Chem 70: 154-64 (2013) Article DOI: 10.1016/j.ejmech.2013.07.034 BindingDB Entry DOI: 10.7270/Q2DR2ZF3
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50095287 (CHEMBL3085880) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Modulation of human Nav1.7 by automated patch clamp electrophysiology assay				Eur J Med Chem 70: 154-64 (2013) Article DOI: 10.1016/j.ejmech.2013.07.034 BindingDB Entry DOI: 10.7270/Q2DR2ZF3
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair