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SMILES: COc1ccc(Cl)cc1-c1ccc(NC(=O)c2ccnn2C)nc1N

InChI Key: InChIKey=CNEOXGXBLPJVNS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50095332   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))		BDBM50095332
PNG
(CHEMBL3589905)
Show SMILES COc1ccc(Cl)cc1-c1ccc(NC(=O)c2ccnn2C)nc1N
Show InChI InChI=1S/C17H16ClN5O2/c1-23-13(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(18)3-5-14(12)25-2/h3-9H,1-2H3,(H3,19,21,22,24)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay

ACS Med Chem Lett 6: 650-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ
More data for this
Ligand-Target Pair