BDBM50095348 CHEMBL3589036
SMILES: CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(c1)C(F)(F)F
InChI Key: InChIKey=CNSBKLBZNFFFRD-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-arginine N-methyltransferase 1 (Homo sapiens (Human)) | BDBM50095348 (CHEMBL3589036) | PDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA... | ACS Med Chem Lett 6: 655-9 (2015) Article DOI: 10.1021/acsmedchemlett.5b00071 BindingDB Entry DOI: 10.7270/Q20003V2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein arginine N-methyltransferase 6 (Homo sapiens (Human)) | BDBM50095348 (CHEMBL3589036) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 327 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. Curated by ChEMBL | Assay Description Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA... | ACS Med Chem Lett 6: 655-9 (2015) Article DOI: 10.1021/acsmedchemlett.5b00071 BindingDB Entry DOI: 10.7270/Q20003V2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein arginine methyltransferase 8 (PRMT8) (Homo sapiens (Human)) | BDBM50095348 (CHEMBL3589036) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [... | ACS Med Chem Lett 6: 655-9 (2015) Article DOI: 10.1021/acsmedchemlett.5b00071 BindingDB Entry DOI: 10.7270/Q20003V2 | |||||||||||
More data for this Ligand-Target Pair |