BDBM50095502 4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid::CHEMBL196421::CHEMBL358506
SMILES: OC(=O)C(=O)CC(=O)c1ccc(Cc2ccccc2)s1
InChI Key: InChIKey=PHCFKAVFHIELCJ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1) | BDBM50095502 (4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay. | J Med Chem 43: 4923-6 (2001) BindingDB Entry DOI: 10.7270/Q2930SFS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1) | BDBM50095502 (4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Messina Curated by ChEMBL | Assay Description Strand transfer inhibitory activity against HIV-1 integrase | J Med Chem 48: 7084-8 (2005) Article DOI: 10.1021/jm050549e BindingDB Entry DOI: 10.7270/Q27W6BR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus) | BDBM50095502 (4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid ...) | UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Rome La Sapienza Curated by ChEMBL | Assay Description Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer) | J Med Chem 48: 6304-14 (2005) Article DOI: 10.1021/jm0504454 BindingDB Entry DOI: 10.7270/Q2T43SNM | |||||||||||
More data for this Ligand-Target Pair |