BDBM50095570 4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyridin-4-yloxy)-benzenesulfonyl]-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL343414

SMILES: Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O

InChI Key: InChIKey=LUCWASGSJPPQEE-SUMWQHHRSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50095570   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Collagenase 3 (Homo sapiens (Human))	BDBM50095570 (4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...) Show SMILES Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O Show InChI InChI=1S/C20H21N5O7S/c1-23-12-18(26)25(20(23)28)13-10-17(19(27)22-29)24(11-13)33(30,31)16-4-2-14(3-5-16)32-15-6-8-21-9-7-15/h2-9,12-13,17,26,29H,10-11H2,1H3,(H,22,27)/t13-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)				J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50095570 (4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...) Show SMILES Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O Show InChI InChI=1S/C20H21N5O7S/c1-23-12-18(26)25(20(23)28)13-10-17(19(27)22-29)24(11-13)33(30,31)16-4-2-14(3-5-16)32-15-6-8-21-9-7-15/h2-9,12-13,17,26,29H,10-11H2,1H3,(H,22,27)/t13-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloproteinase -1 (collagenase-1)				J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW
					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM50095570 (4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...) Show SMILES Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O Show InChI InChI=1S/C20H21N5O7S/c1-23-12-18(26)25(20(23)28)13-10-17(19(27)22-29)24(11-13)33(30,31)16-4-2-14(3-5-16)32-15-6-8-21-9-7-15/h2-9,12-13,17,26,29H,10-11H2,1H3,(H,22,27)/t13-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50095570 (4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...) Show SMILES Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O Show InChI InChI=1S/C20H21N5O7S/c1-23-12-18(26)25(20(23)28)13-10-17(19(27)22-29)24(11-13)33(30,31)16-4-2-14(3-5-16)32-15-6-8-21-9-7-15/h2-9,12-13,17,26,29H,10-11H2,1H3,(H,22,27)/t13-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloproteinase -3 (stromelysin)				J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW
					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM50095570 (4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...) Show SMILES Cn1cc(O)n([C@H]2C[C@@H](N(C2)S(=O)(=O)c2ccc(Oc3ccncc3)cc2)C(=O)NO)c1=O Show InChI InChI=1S/C20H21N5O7S/c1-23-12-18(26)25(20(23)28)13-10-17(19(27)22-29)24(11-13)33(30,31)16-4-2-14(3-5-16)32-15-6-8-21-9-7-15/h2-9,12-13,17,26,29H,10-11H2,1H3,(H,22,27)/t13-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against matrix metalloproteinase-7 (matrilysin, MMP-7)				J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW
					More data for this Ligand-Target Pair