BDBM50095592 4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benzenesulfonyl]-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL148178
SMILES: CS(=O)(=O)N[C@H]1C[C@@H](N(C1)S(=O)(=O)c1ccc(Oc2ccncc2)cc1)C(=O)NO
InChI Key: InChIKey=DZVJLUYVLJYLGY-BLLLJJGKSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Matrilysin (Homo sapiens (Human)) | BDBM50095592 (4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibitory activity against matrix metalloproteinase-7 (matrilysin, MMP-7) | J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50095592 (4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibitory activity against matrix metalloproteinase -1 (collagenase-1) | J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM50095592 (4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3) | J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50095592 (4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibitory activity against matrix metalloproteinase -3 (stromelysin) | J Med Chem 43: 4948-63 (2001) BindingDB Entry DOI: 10.7270/Q21N80DW | |||||||||||
More data for this Ligand-Target Pair |