BDBM50097240 (R)-N*1*-((S)-1-Cyclohexylcarbamoyl-2,2-dimethyl-propyl)-N*4*-hydroxy-2-(3-phenyl-propyl)-succinamide::(R)-N1-((S)-1-(cyclohexylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide::CHEMBL157112

SMILES: CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1

InChI Key: InChIKey=WTMNDZGXJUPIBE-DENIHFKCSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50097240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097240 ((R)-N*1*-((S)-1-Cyclohexylcarbamoyl-2,2-dimethyl-p...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1 Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)/t19-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Ability to inhibit the matrix metalloprotease-2 by method of Knight et al using the fluorogenic peptide substrate.				Bioorg Med Chem Lett 11: 567-70 (2001) BindingDB Entry DOI: 10.7270/Q2610ZK1
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097240 ((R)-N*1*-((S)-1-Cyclohexylcarbamoyl-2,2-dimethyl-p...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1 Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)/t19-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097240 ((R)-N*1*-((S)-1-Cyclohexylcarbamoyl-2,2-dimethyl-p...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1 Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)/t19-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097240 ((R)-N*1*-((S)-1-Cyclohexylcarbamoyl-2,2-dimethyl-p...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1 Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)/t19-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Ability to inhibit the matrix metalloprotease-3 by method of Knight et al using the fluorogenic peptide substrate.				Bioorg Med Chem Lett 11: 567-70 (2001) BindingDB Entry DOI: 10.7270/Q2610ZK1
					More data for this Ligand-Target Pair