BDBM50097265 (R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-2-[2-(4'-fluoro-biphenyl-4-yl)-ethyl]-N*4*-hydroxy-succinamide::CHEMBL348878

SMILES: C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCc1ccc(cc1)-c1ccc(F)cc1)CC(=O)NO)C(C)(C)C)c1ccccc1

InChI Key: InChIKey=ZFQPFNFJKNLTIW-KFACBJOOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50097265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097265 ((R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylca...) Show SMILES C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCc1ccc(cc1)-c1ccc(F)cc1)CC(=O)NO)C(C)(C)C)c1ccccc1 Show InChI InChI=1S/C32H38FN3O4/c1-21(23-8-6-5-7-9-23)34-31(39)29(32(2,3)4)35-30(38)26(20-28(37)36-40)15-12-22-10-13-24(14-11-22)25-16-18-27(33)19-17-25/h5-11,13-14,16-19,21,26,29,40H,12,15,20H2,1-4H3,(H,34,39)(H,35,38)(H,36,37)/t21-,26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097265 ((R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylca...) Show SMILES C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCc1ccc(cc1)-c1ccc(F)cc1)CC(=O)NO)C(C)(C)C)c1ccccc1 Show InChI InChI=1S/C32H38FN3O4/c1-21(23-8-6-5-7-9-23)34-31(39)29(32(2,3)4)35-30(38)26(20-28(37)36-40)15-12-22-10-13-24(14-11-22)25-16-18-27(33)19-17-25/h5-11,13-14,16-19,21,26,29,40H,12,15,20H2,1-4H3,(H,34,39)(H,35,38)(H,36,37)/t21-,26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097265 ((R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylca...) Show SMILES C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCc1ccc(cc1)-c1ccc(F)cc1)CC(=O)NO)C(C)(C)C)c1ccccc1 Show InChI InChI=1S/C32H38FN3O4/c1-21(23-8-6-5-7-9-23)34-31(39)29(32(2,3)4)35-30(38)26(20-28(37)36-40)15-12-22-10-13-24(14-11-22)25-16-18-27(33)19-17-25/h5-11,13-14,16-19,21,26,29,40H,12,15,20H2,1-4H3,(H,34,39)(H,35,38)(H,36,37)/t21-,26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair