BDBM50098772 3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (2,4,6-trimethyl-phenyl)-amide::CHEMBL277595
SMILES: Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2c(C)cc(C)cc2C)c1Cl
InChI Key: InChIKey=VMRGBLIETYGKNV-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50098772 (3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Biotechnology Corporation Curated by ChEMBL | Assay Description Inhibitory concentration was determined against selective Endothelin A receptor | J Med Chem 44: 1211-6 (2001) BindingDB Entry DOI: 10.7270/Q2Z89BN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50098772 (3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of I-ET-1 binding to human Endothelin A receptor | Bioorg Med Chem Lett 7: 933-938 (1997) Article DOI: 10.1016/S0960-894X(97)00132-7 BindingDB Entry DOI: 10.7270/Q2DV1JWM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRA (RAT) | BDBM50098772 (3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Encysive Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory concentration towards endothelin A receptor in rat. | J Med Chem 47: 1969-86 (2004) Article DOI: 10.1021/jm030528p BindingDB Entry DOI: 10.7270/Q2HD7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50098772 (3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay | Bioorg Med Chem Lett 7: 939-944 (1997) Article DOI: 10.1016/S0960-894X(97)00133-9 BindingDB Entry DOI: 10.7270/Q2959HKC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (Homo sapiens (Human)) | BDBM50098772 (3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 8.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of I-ET-1 binding to human Endothelin B receptor | Bioorg Med Chem Lett 7: 933-938 (1997) Article DOI: 10.1016/S0960-894X(97)00132-7 BindingDB Entry DOI: 10.7270/Q2DV1JWM | |||||||||||
More data for this Ligand-Target Pair |