BDBM50099326 8-{(S)-1-Methyl-2-[4-(2,4,5-trifluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL274864::SNAP-8719
SMILES: C[C@@H](CN1CCN(CC1)c1cc(F)c(F)cc1F)N1C(=O)CC2(CCCC2)CC1=O
InChI Key: InChIKey=WCWNYVYNQAPOOX-HNNXBMFYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50099326 (8-{(S)-1-Methyl-2-[4-(2,4,5-trifluoro-phenyl)-pipe...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc. Curated by ChEMBL | Assay Description Binding affinity for human Alpha-1D adrenergic receptor | J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50099326 (8-{(S)-1-Methyl-2-[4-(2,4,5-trifluoro-phenyl)-pipe...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 302 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Displacement of [3H]-8-OHDPAT from 5-HT1A receptor in rat hippocampal membranes after 30 mins | J Med Chem 56: 6402-12 (2013) Article DOI: 10.1021/jm400867d BindingDB Entry DOI: 10.7270/Q2NV9N63 | |||||||||||
More data for this Ligand-Target Pair |