BDBM50100278 2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL24888

SMILES: COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC

InChI Key: InChIKey=KISBCVMWQAXCRV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50100278 (2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...) Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...				Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50100278 (2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...) Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.				Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat))	BDBM50100278 (2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...) Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...				Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS
					More data for this Ligand-Target Pair