BDBM50100666 6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester::CHEMBL70432

SMILES: COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C

InChI Key: InChIKey=SAIANZNAZKQKDP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50100666 (6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-p...) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C Show InChI InChI=1S/C23H25NO8/c1-24-20(23(26)32-7)19(12-8-17(29-4)21(31-6)18(9-12)30-5)13-10-15(27-2)16(28-3)11-14(13)22(24)25/h8-11H,1-7H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Rattus norvegicus)	BDBM50100666 (6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-p...) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C Show InChI InChI=1S/C23H25NO8/c1-24-20(23(26)32-7)19(12-8-17(29-4)21(31-6)18(9-12)30-5)13-10-15(27-2)16(28-3)11-14(13)22(24)25/h8-11H,1-7H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against rat heart Phosphodiesterase 1(PDE1)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50100666 (6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-p...) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C Show InChI InChI=1S/C23H25NO8/c1-24-20(23(26)32-7)19(12-8-17(29-4)21(31-6)18(9-12)30-5)13-10-15(27-2)16(28-3)11-14(13)22(24)25/h8-11H,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair