BDBM50101665 5-Acetyl-4-{4-[4-(5-chloro-2-methoxy-phenyl)-piperazin-1-yl]-butylamino}-2,6-dimethyl-2H-pyridazin-3-one::CHEMBL420959
SMILES: COc1ccc(Cl)cc1N1CCN(CCCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1
InChI Key: InChIKey=LQABNCQTZIOQJK-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50101665 (5-Acetyl-4-{4-[4-(5-chloro-2-methoxy-phenyl)-piper...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Chimico Farmaceutico e Tossicologico Curated by ChEMBL | Assay Description Binding affinity towards human cloned 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand | J Med Chem 44: 2403-10 (2001) BindingDB Entry DOI: 10.7270/Q2WS8SHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50101665 (5-Acetyl-4-{4-[4-(5-chloro-2-methoxy-phenyl)-piper...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Chimico Farmaceutico e Tossicologico Curated by ChEMBL | Assay Description Binding affinity towards human cloned alpha1A-adrenoceptor using [3H]-prazosin as radioligand | J Med Chem 44: 2403-10 (2001) BindingDB Entry DOI: 10.7270/Q2WS8SHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50101665 (5-Acetyl-4-{4-[4-(5-chloro-2-methoxy-phenyl)-piper...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Chimico Farmaceutico e Tossicologico Curated by ChEMBL | Assay Description Binding affinity towards human cloned alpha1d-adrenoceptor using [3H]-prazosin as radioligand | J Med Chem 44: 2403-10 (2001) BindingDB Entry DOI: 10.7270/Q2WS8SHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50101665 (5-Acetyl-4-{4-[4-(5-chloro-2-methoxy-phenyl)-piper...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 49.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Chimico Farmaceutico e Tossicologico Curated by ChEMBL | Assay Description Binding affinity towards human cloned alpha1B-adrenoceptor using [3H]-prazosin as radioligand | J Med Chem 44: 2403-10 (2001) BindingDB Entry DOI: 10.7270/Q2WS8SHW | |||||||||||
More data for this Ligand-Target Pair |